Pimonidazole hydrochloride
CAS No. 70132-51-3
Pimonidazole hydrochloride ( —— )
Catalog No. M26788 CAS No. 70132-51-3
Pimonidazole hydrochloride accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after the reduction of its nitro group.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
10MG | 37 | Get Quote |
|
25MG | 79 | Get Quote |
|
50MG | 149 | Get Quote |
|
100MG | 258 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NamePimonidazole hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionPimonidazole hydrochloride accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after the reduction of its nitro group.
-
DescriptionPimonidazole hydrochloride accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after the reduction of its nitro group. It can be used for qualitative and quantitative assessment of tumor hypoxia. Pimonidazole hydrochloride is a novel hypoxia marker for the complementary study of tumor hypoxia and cell proliferation in tumors.(In Vitro):Pimonidazole, the exogenous hypoxia marker, is a 2-nitroimidazole compound, which forms covalent bonds with cellular macromolecules at oxygen levels below 1.3%.(In Vivo):Pimonidazole is a 2-nitroimidazole that is reductively activated specifically in hypoxic cells and forms stable adducts with thiol groups in proteins, peptides, and amino acids. Additionally, the amount of pimonidazole that is detected is directly proportional to the level of hypoxia within tumors in vivo.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
Recptorα4β2 nAChR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number70132-51-3
-
Formula Weight290.8
-
Molecular FormulaC11H19ClN4O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCl.OC(CN1CCCCC1)Cn1ccnc1[N+]([O-])=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Yildirim E, et al. ABT-089, but not ABT-107, ameliorates nicotine withdrawal-induced cognitive deficits in C57BL6/J mice. Behav Pharmacol. 2015 Apr;26(3):241-8.
molnova catalog
related products
-
Pulsatilloside E
Pulsatilloside E is a natural product isolated from the roots of Pulsatilla chinensis (Ranunculaceae).
-
Myricetin 3-O-beta-D...
Myricetin 3-O-beta-D-xylopyranosyl(1-2)-beta-D-glucopyranoside is a natural product for research related to life sciences.
-
6-Bromo-2-hydroxy-3-...
6-Bromo-2-hydroxy-3-methoxybenzaldehyde is an inhibitor of IRE-1α (IC50 : 0.08 μM).